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EMBO Member

Šárka Pospíšilová

Masaryk University, Brno | Czech Republic

EMBO 2022

p53 abnormalities and clonal evolution of leukemia

My research team is interested in the role and analysis of antioncogene TP53 and other cancer-related genes in lymphoid malignancies. TP53 abnormalities are frequently associated with evolution of tumour clones, chromothripsis and poor patients' outcome. Genomic approaches enable us to characterize a molecular background of the disease, analyse pathogenic pathways associated with tumor development, and monitor genetic drivers of clonal expansion.

Keywords: TP53 gene abnormalities / immunoglobulin genes / gene mutations / clonal evolution / cancer genomics / chronic lymphocytic leukemia (CLL) / lymphoid malignancies

Subject area(s): Genomic & Computational Biology | Immunology | Molecular Medicine