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EMBO Young Investigator

Arun Shukla

Indian Institute of Technology, Kanpur | India

YIP 2018

Structure, function and modulation of GPCRs

Our goal is to understand the structural basis of activation and signaling of selected GPCRs, and ultimately leverage this information to improve therapeutic manipulation in human diseases. We utilize synthetic chaperones generated through combinatorial biology and directed evolution approaches to capture and visualize distinct conformational states of GPCRs and their signaling complexes.

Keywords: Structural biology / cellular signaling / membrane proteins / GPCRs / drug discovery / synthetic & chemical biology

Subject area(s): Signal Transduction | Structural Biology & Biophysics