Structure, function and modulation of GPCRs
Our goal is to understand the structural basis of activation and signaling of selected GPCRs, and ultimately leverage this information to improve therapeutic manipulation in human diseases. We utilize synthetic chaperones generated through combinatorial biology and directed evolution approaches to capture and visualize distinct conformational states of GPCRs and their signaling complexes.
Keywords
Structural biology / cellular signaling / membrane proteins / GPCRs / drug discovery / synthetic & chemical biology