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Epigenetic regulation of the X chromosome in flies

The major goal of our group is to study the chromatin and epigenetic mechanisms underlying gene regulation using dosage compensation as a model system. Dosage compensation in Drosophila is a powerful model system to study chromatin and transcription regulation at individual gene level as well from a chromosomal perspective. In order to achieve that we are employing biochemical, genetic, genomic and structural methodologies.