Wellcome Trust Centre for Stem Cell Research, Cambridge | United Kingdom
EMBO 2004 | MemC 09–12
We study embryonic stem (ES) cells and derivative tissue stem cells. Our goal is to understand the molecular foundations of self-renewal and commitment. We are investigating determinants of the decision to retain or exit pluripotency and the mechanism of lineage choice. We are also interested in the relationship between stem cell lines propagated in culture and progenitor cells in vivo.
Keywords: Stem cells / pluripotency / self-renewal / lineage commitment / embryo