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EMBO Member

Austin Smith

Wellcome Trust Centre for Stem Cell Research, Cambridge | United Kingdom

EMBO 2004 | MemC 09–12

Pluripotency, self-renewal and lineage commitment

We study embryonic stem (ES) cells and derivative tissue stem cells. Our goal is to understand the molecular foundations of self-renewal and commitment. We are investigating determinants of the decision to retain or exit pluripotency and the mechanism of lineage choice. We are also interested in the relationship between stem cell lines propagated in culture and progenitor cells in vivo.

Keywords: Stem cells / pluripotency / self-renewal / lineage commitment / embryo

Subject area(s): Development | Differentiation & Death | Signal Transduction