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EMBO Young Investigator

Axel Innis

Institut Européen de Chimie et Biologie (IECB), Pessac | France

YIP 2018

How nascent and free peptides regulate translation

My group uses combined biochemical, structural and computational approaches to study some of the key events that take place within the functional nano-environment of the ribosomal exit tunnel. This includes translational arrest induced by nascent polypeptides known as arrest peptides, and bacterial ribosome inhibition by antimicrobial peptides or antibiotics.

Keywords: Ribosome / arrest peptides / protein synthesis / translation / antibiotics / antimicrobial peptides / gene regulation / metabolite sensing

Subject area(s): Microbiology, Virology & Pathogens | Proteins & Biochemistry | Structural Biology & Biophysics