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EMBO Member

Beatrice Vallone

University of Rome 'Sapienza', Rome | Italy

EMBO 2020

Protein structure and dynamics

We study the structure-function relationship in proteins and their complexes. We adopt an integrated structural biology approach to obtain a dynamic picture of proteins (X-ray crystallography, X-ray scattering and cryo-electron microscopy). Our research includes complexes between plasma proteins and their receptors, neuroglobin and P450 cytochromes involved in antibiotic synthesis. We analyse protein function and dynamics using a range of biochemical methods, including kinetics and spectroscopy.

Keywords: Integrated structural biology / heme proteins / iron transport / host-pathogen interactions / protein structural dynamics / membrane proteins / protein engineering

Subject area(s): Microbiology, Virology & Pathogens | Molecular Medicine | Proteins & Biochemistry | Structural Biology & Biophysics