Molecular mechanisms of neurodegerative diseases
My group aims to define the molecular mechanisms of protein aggregation that lead to neurodegenerative diseases. To this end, we combine structural and cell biology approaches, utilising electron cryo-microscopy (cryo-EM) techniques with patient samples and advanced cellular models. An understanding of these mechanisms may provide successful strategies for the timely diagnosis and treatment of neurodegenerative diseases.
Keywords
Neurodegenerative disease / protein aggregation / cryo-electron microscopy / cryo-electron tomography