Stem cells and fate choices during mouse embryogenesis
My group investigates how regulatory genes, including lncRNAs, orchestrate organ development in the mouse embryo. In particular we are interested in the organization of trunk and tail development, and focus on the genetic and epigenetic control of fate choice in descendants of stem/progenitor cells. Another research topic of my lab is the genetic basis of non-Mendelian inheritance revealed by the mouse t-haplotype.
Keywords
Mammalian developmental genetics / stem cells / fate choice / mesoderm formation / organogenesis / long non-coding RNA / gene regulation networks / non-Mendelian inheritance / tumor genetics