Helical complexes in immunology
Our group aims to unravel and harness the molecular details of complex signaling events in immunology. On the information input side, we mainly utilize structural biology tools, to obtain atomic-level molecular details of how cellular immune signal propagation is achieved in host cells. On the biotech/technology output side, we engineer enzymatic tools to manipulate components of the host immune system.
Keywords
CARD domain filament / inflammasome / cryo-EM / protein ligase / innate immunity