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EMBO Member

Bożena Kamińska-Kaczmarek

Nencki Institute of Experimental Biology, Warsaw | Poland

EMBO 2022

Tumor microenvironment at single-cell resolution

We explore the role of tumor genetic heterogeneity in shaping microenvironment and reciprocal tumor-immune interactions in tumor progression and responses to therapeutic intervention. We interrogate TME using single-cell omics, immune phenotyping, 3D co-cultures, mouse models of brain tumors, multi-modal in vivo imaging. We attempt to find tumor vulnerabilities and develop targeted therapies interrupting tumor-microenvironment interactions.

Keywords: Brain tumors / tumor microenvironment / single-cell omics / antitumor immunity / transcription regulation / epigenetic memory / immunotherapy

Subject area(s): Chromatin & Transcription | Differentiation & Death | Immunology | Molecular Medicine