EMBO Member
Boris Turk
EMBO 2007 | FelC 21–24
Josef Stefan Institute, Ljubljana, Slovenia
Proteases in inflammation-associated diseases
My research focuses on the understanding of the molecular mechanisms underlying the involvement of proteases, in particular lysosomal cysteine cathepsins, in inflammation-associated diseases, such as cancer and arthritis. These include identification of their physiological substrates and development of novel approaches for non-invasive in-vivo imaging, including chemical biology and protein engineering, as well as targeted drug delivery.
Keywords
Protease signaling / cysteine cathepsins / inflammation-associated diseases / degradomics / protein processing & degradation / noninvasive in vivo imaging / regulation & physiology