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EMBO Member

Boris Turk

Josef Stefan Institute, Ljubljana | Slovenia

EMBO 2007 | FelC 21–24

Proteases in inflammation-associated diseases

My research focuses on the understanding of the molecular mechanisms underlying the involvement of proteases, in particular lysosomal cysteine cathepsins, in inflammation-associated diseases, such as cancer and arthritis. These include identification of their physiological substrates and development of novel approaches for non-invasive in-vivo imaging, including chemical biology and protein engineering, as well as targeted drug delivery.

Keywords: Protease signaling / cysteine cathepsins / inflammation-associated diseases / degradomics / protein processing & degradation / noninvasive in vivo imaging / regulation & physiology

Subject area(s): Differentiation & Death | Molecular Medicine | Proteins & Biochemistry