Mechanisms and functions of ubiquitylation
We seek to elucidate molecular principles of the ubiquitin system: how are ubiquitin and ubiquitin-like protein modifications matched with specific substrates? And how do they alter the functions of their targets? We integrate cell biology, biochemistry, structure, chemistry and genetics to identify novel regulatory pathways, and to visualize structures of fleeting multiprotein assemblies catalyzing ubiquitylation reactions.
Keywords
Ubiquitin / ubiquitin-like proteins / mechanism of ubiquitylation / cell cycle control / NEDD8 / cullin-RING ligases / HECT E3s / RBR E3s