NDR kinases are conserved from yeast to man. Knock-out models in yeast and fly indicate that the respective Ndr homologs serve essential functions. The mammalian genome encodes four NDR kinases, namely NDR1/2 and LATS1/2. Both NDR and LATS are activated by MST kinases, the central component of the Hippo pathway. We aim to decipher the contribution of NDR to the Hippo pathway and beyond.
Keywords: Signal transduction / protein kinase regulation / mouse models