National University of Ireland, Galway | Ireland
Nucleoli, sites of ribosome biogenesis, are the largest structures in the human nucleus. They form around arrays of ribosomal genes (rDNA), nucleolar organiser regions (NORs), located on the poorly characterised p-arms of the five acrocentric chromosomes. My research is aimed at describing the chromosomal context of human NORs, determining how this influences nucleolar formation, organisation and rDNA genomic stability.
Keywords: Nucleolus / ribosomal genes (rDNA) / DNA damage / nuclear organisation / human genome organisation / human acrocentric chromosomes / nucleolar organiser regions