Membrane shaping and actin dynamics
Our group examines mechanisms that shape membranes into defined topologies and unravels their linkages to local actin cytoskeletal dynamics. Especially for neurons and neuronal networks, specialized membrane domains and compartments are prerequisites for proper development, function and plastic adaptations. We study the underlying mechanisms and thereby unravel basic principles of life but also associated pathophysiological conditions.
Keywords
Neuronal development, plasticity and disease pathophysiology / membrane dynamics / membrane curvature / membrane shaping proteins / BAR domains / N-Ank proteins / actin cytoskeleton / actin nucleation