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EMBO Associate Member

Bruce Beutler

University of Texas Southwestern Medical Center, Dallas | United States

EMBO 2009

We investigate the immune response, and other biological phenomena, using random germline mutagenesis. Toward this end, we have worked to develop methods for high speed positional cloning in mammals. These methods allow simultaneous detection of phenotype and assignment of mutational cause.

Keywords: Mutagenesis / innate immunity / mouse / inflammation / Toll-like receptors

Subject area(s): Genomic & Computational Biology | Immunology