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Targeting disease mechanisms in MYC-driven cancer

We study disease mechanisms and therapeutic opportunities in MYC-driven cancers. These tumors show 'oncogene addiction', implying that MYC itself – and presumably a subset of its target genes – are required for tumor maintenance. Moreover, the fitness of MYC-overexpressing cells depends on a fragile equilibrium between conflicting stress signals, providing opportunities to exploit synthetic lethality as a strategy for therapeutic intervention.