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EMBO Member

Bruno Silva-Santos

Instituto de Medicina Molecular João Lobo Antunes, Lisbon | Portugal

EMBO 2019

T cell functions in healthy and malignant tissues

We study the biology of T lymphocytes, with a special focus on gamma-delta T cells, and their key roles in tissue (patho)physiology. In the disease setting, we employ murine models of infection, inflammatory diseases and cancer. We also investigate human T cell differentiation and functions, aiming at an improved molecular understanding of these processes and, ultimately, at the development of novel immunotherapeutic approaches for cancer.

Keywords: T cells / differentiation / thymus / cytokines / tumor immunology

Subject area(s): Chromatin & Transcription | Immunology | Molecular Medicine

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