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EMBO Young Investigator

Bungo Akiyoshi

University of Oxford | United Kingdom

YIP 2017

Unconventional kinetoplastid kinetochores

My group studies kinetochores in evolutionarily-distant eukaryotes, called kinetoplastids. We discovered a unique set of kinetochore proteins (KKT1–20) in Trypanosoma brucei, a kinetoplastid parasite that causes sleeping sickness in humans. We are currently characterizing the function of these unconventional kinetochore proteins to reveal fundamental principles of the eukaryotic segregation machinery.

Keywords: Kinetochore / mitosis / chromosome / trypanosome / kinetoplastid / centromere / Trypanosoma brucei

Subject area(s): Cell Cycle | Structural Biology & Biophysics | Evolution & Ecology