Mechanisms of cell wall assembly in pathogens
My lab aims to unravel the molecular mechanisms of membrane proteins participating in cell wall assembly, and to establish strategies to counteract bacterial pathogens. We combine single-particle cryo-EM, X-ray crystallography, and in-vitro and in-vivo functional characterization of proteins to show how cell wall biopolymers are assembled, transported, and how they contribute to immune evasion, adaptation, and virulence.
Keywords
Bacterial pathogens / cell wall assembly / lipid & solute transport / cryo-EM / crystallography / membrane protein biophysics