
EMBO Member
Carl-Henrik Heldin
EMBO 1989 | MemC 05–08 | Council 08–10 | Council 15–17 | Council 16–20 | Council 18–20
Mechanism of action of growth regulatory factors
My research focuses on the mechanisms whereby growth factors, in particular PDGF and TGF-beta, activate their receptors and control cell growth, migration, apoptosis and differentiation, and how perturbations of signaling pathways promote tumor progression. An aim is to explore the usefulness of signal transduction inhibitors for tumor treatment.
Keywords
Molecular mechanisms of cellular growth control / structural & functional characterization of growth regulatory factors / signal transduction