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EMBO Member

Caroline Dive

Cancer Research UK Manchester Institute, Manchester | United Kingdom

EMBO 2020

Biomarkers to support cancer treatment decisions

I run a Biomarker Centre supporting cancer precision medicine and earlier detection of cancers. We develop and validate assays for biomarker-driven clinical trials with an emphasis on liquid biopsies. We also study small cell lung cancer and pioneered mouse models derived from circulating tumour cells used to subtype this recalcitrant disease, discover new vulnerabilities and develop personalised therapeutic strategies.

Keywords: Lung cancer / circulating tumour cells (CTCs) / CTC based mouse models (CDX) / liquid biopsies / biomarkers / experimental cancer therapeutics / early cancer detection / digital clinical trials

Subject area(s): Genomic & Computational Biology | Molecular Medicine