Francis Crick Institute, London | United Kingdom
EMBO 2002 | FelC 08–11 | MemC 15–18
The work in my laboratory focuses on the signalling and function of Transforming Growth Factor beta (TGF-beta) superfamily ligands, which include TGF-betas, Activins, Nodals, BMPs and GDFs. We want to understand the mechanism whereby these ligands signal from the plasma membrane to the nucleus, determine how they function and are regulated in embryonic development and untransformed adult cells, and how their activity is perturbed in cancer.
Keywords: TGF-beta superfamily / SMAD signaling / transcription / tumorigenesis / BMP / nodal / activin / Xenopus / zebrafish / chromatin