EMBO Young Investigator
Cécile Charrier
YIP 2020–2024
Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Paris, France
Development and human evolution of synapses
My laboratory studies the molecular basis of synapse development and plasticity by focusing on molecular pathways that are linked to human evolution. Our goal is to understand fundamental principles that are common to all mammals and uncover regulations that are specific to humans. We use in-vivo manipulations in intact mouse cortical circuits, microscopy, electrophysiology, proteomics and neurons derived from human pluripotent stem cells.
Keywords
Synapse / synaptogenesis / synaptic plasticity / human brain evolution / postsynaptic scaffold / neuron / dendrite