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EMBO Global Investigator

Cesar A. Ramirez Sarmiento

Pontifical Catholic University of Chile, Santiago de Chile | Chile

GIN 2023–2026

Evolution of metamorphic proteins & PET hydrolases

Our research group employs experimental and computational strategies to unveil the folding-function-evolution relationships of metamorphic proteins, prototypical models to understand the emergence of novel protein folds in nature, and of bacterial enzymes that hydrolyze PET, a widely used plastic that accumulates as waste in landfills and natural environments at similar rates to its production.

Keywords: Protein folding / metamorphic proteins / biocatalysis / plastic degradation / molecular evolution

Subject area(s): Genomic & Computational Biology | Proteins & Biochemistry | Structural Biology & Biophysics | Evolution & Ecology