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EMBO Member

Christian Lüscher

University, Geneva | Switzerland

EMBO 2025

Circuit mechanisms of addiction and overeating

Our work defined how addictive drugs hijack mesolimbic dopamine via activation, disinhibition, or reuptake blockade. We identified drug-evoked synaptic plasticity as a driver of compulsive use and mapped accumbens-hypothalamus circuits in hedonic overeating. We pioneered optogenetically inspired neuromodulation informed by circuit mapping in rodent models.

Keywords: addiction / reward learning / neural circuits / optogenetics / dopamine / synaptic plasticity/ obesity

Subject area(s): Molecular Medicine | Neuroscience | Signal Transduction

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