EMBO Member

Christian Spahn

Charité, Berlin | Germany

EMBO 2014

Structure and function of macromolecular machines

My lab is using cryo-electron microscopy in combination with digital image processing to study the structure and structural dynamics of large macromolecular assemblies and machines. A particular focus of my group is on ribosomes. Here, we are studying the molecular mechanism of translation in all domains of life as well as translational control, e.g. by regulatory sequences in the mRNA.

Keywords: 3D cryo-EM / ribosomes / protein biosynthesis / translational control / macromolecular machines

Subject area(s): Proteins & Biochemistry | RNA | Structural Biology & Biophysics