University of Cambridge | United Kingdom
We are trying to understand the mechanisms that underlie the assembly of neural connections in the vertebrate visual system. Axons from retinal ganglion cells in the eye navigate over a long distance with remarkable accuracy to reach their synaptic targets in the brain. Increasing evidence points to a significant role for post-transcriptional mechanisms in this process and our work focuses on RNA localization and axonal protein synthesis.
Keywords: Axon guidance / growth cone / retina / visual pathway / protein synthesis / RNA trafficking / topographic mapping / axon maintenance