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EMBO Member

Christoph W. Müller

EMBL, Heidelberg | Germany

EMBO 2005 | CouC 08–11 | EEsC 08–11 | GinC 24–27

Molecular mechanisms of transcriptional regulation

My group uses biophysical and biochemical approaches to learn about the molecular mechanisms of transcription regulation in eukaryotes, where DNA is packaged into chromatin. In the context of chromatin, we are interested in DNA-recognition by transcription factors, their interactions with co-activators, general transcription factors and chromatin remodelers and how RNA polymerases are recruited to the transcription start site.

Keywords: Structural biology / transcriptional regulation / chromatin / RNA polymerase I / RNA polymerase III

Subject area(s): Chromatin & Transcription | Proteins & Biochemistry | Structural Biology & Biophysics