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EMBO Member

Christopher G. Tate

MRC LMB, Cambridge | United Kingdom

EMBO 2020

Structure and function of membrane proteins

Our lab uses cryo-EM and X-ray crystallography to determine the structures of G protein-coupled receptors (GPCRs) in different conformational states and in complex with signalling proteins such as arrestin and G proteins. In combination with pharmacological analyses and biophysical data, these structures allow us to decipher the molecular basis for receptor activation, ligand efficacy, G protein specificity and bias signalling.

Keywords: Membrane protein / G protein-coupled receptor / thermostabilisation / structure / mechanism

Subject area(s): Membranes & Transport | Signal Transduction | Structural Biology & Biophysics