Regulation of protein biosynthesis by oxygen
Our group works on roles of oxygenases in the regulation of protein biosynthesis and modification, with emphasis on 2-oxoglutarate dependent oxygenases. These enzymes have roles in transcriptional regulation via catalysis of post-translational hydroxylations and demethylations on histone and transcription factors. Related enzymes are involved in translational regulation via ribosomal protein modification. Other interests include combatting antimicrobial resistance and antibiotic biosynthesis.
Keywords
Oxygenases / transcriptional and translational regulation by oxygen / hypoxia / antibiotic biosynthesis / antibiotic mode of action