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EMBO Member

Christopher Schofield

University of Oxford | United Kingdom

EMBO 2014

Regulation of protein biosynthesis by oxygen

Our group works on roles of oxygenases in the regulation of protein biosynthesis and modification, with emphasis on 2-oxoglutarate dependent oxygenases. These enzymes have roles in transcriptional regulation via catalysis of post-translational hydroxylations and demethylations on histone and transcription factors. Related enzymes are involved in translational regulation via ribosomal protein modification. Other interests include combatting antimicrobial resistance and antibiotic biosynthesis.

Keywords: Oxygenases / transcriptional and translational regulation by oxygen / hypoxia / antibiotic biosynthesis / antibiotic mode of action

Subject area(s): Chromatin & Transcription | Proteins & Biochemistry | Structural Biology & Biophysics