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EMBO Member

Claes M. Gustafsson

University, Göteborg | Sweden

EMBO 2022

Mitochondrial gene expression in mammalian cells

My laboratory is focused on studies of gene expression and DNA maintenance in mammalian mitochondria. We use in-vitro biochemistry, structural biology and cell biology to study the underlying enzymatic processes. We also investigate the molecular consequences of disease-causing mutations affecting mitochondrial gene expression and develop new, rational therapeutic approaches.

Keywords: mtDNA / replication / transcription / RNA polymerase / mitochondrial disease

Subject area(s): Cellular Metabolism | Chromatin & Transcription | Genome Stability & Dynamics | Molecular Medicine | Structural Biology & Biophysics