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EMBO Young Investigator

Claire Wyart

Institut du Cerveau et de la Moelle épinière (ICM), Paris | France

YIP 2017

Tasting the cerebrospinal fluid in vertebrates

I have been long fascinated by the fact that the cerebrospinal fluid (CSF) that circulates around the brain and spinal cord can influence brain development and function. My group showed that neurons contacting the CSF in the spinal cord detect mechanical cues and feed back inhibition to circuits driving locomotion and posture. Our recent data reveals mechanisms enabling the detection of CSF-related cues to regulate development and inflammation.

Keywords: Sensory integration / signalling / cerebrospinal fluid / spinal cord / locomotion / posture / optogenetics / zebrafish

Subject area(s): Neuroscience | Development | Signal Transduction