EMBO Member
Claire Wyart
EMBO 2019
Former EMBO Young Investigator (2017)
Institut du Cerveau et de la Moelle Épinière (ICM), Paris, France
Tasting and sensing flow of the cerebrospinal fluid
I am fascinated by how the cerebrospinal fluid (CSF) circulating around the brain and spinal cord influences brain development and functions. My group has discovered a novel sensory organ in the spinal cord relying on neurons interacting with the Reissner fiber in the CSF to sense spinal stretch. CSF-contacting neurons feed back inhibition to motor circuits to adjust locomotion, posture and development of the body axis and spine.
Keywords
Locomotion / spinal cord / motor circuits / sensorimotor integration / cerebrospinal fluid / spine organogenesis / body axis formation