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EMBO Member

Claire Wyart

Institut du Cerveau et de la Moelle Épinière (ICM), Paris | France

EMBO 2019

Tasting and sensing flow of the cerebrospinal fluid

I am fascinated by how the cerebrospinal fluid (CSF) circulating around the brain and spinal cord influences brain development and functions. My group has discovered a novel sensory organ in the spinal cord relying on neurons interacting with the Reissner fiber in the CSF to sense spinal stretch. CSF-contacting neurons feed back inhibition to motor circuits to adjust locomotion, posture and development of the body axis and spine.

Keywords: Locomotion / spinal cord / motor circuits / sensorimotor integration / cerebrospinal fluid / spine organogenesis / body axis formation

Subject area(s): Development | Neuroscience | Signal Transduction | Evolution & Ecology