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EMBO Member

Clare Isacke

Institute of Cancer Research, London | United Kingdom

EMBO 2017

Tumour-stroma interactions in cancer metastasis

Our laboratory studies how tumour cells recruit and activate stromal cells during tumour progression and the colonisation of distant, secondary sites. In addition we study how crosstalk between the tumour cells and the microenvironment modulates therapeutic responses. Our goal is to identify novel strategies for the prevention or suppression of metastatic disease, and to reduce treatment-resistant tumour progression.

Keywords: Cancer cell biology / tumour microenvironment / cell migration and invasion / extracellular matrix / metastasis / pericytes / fibroblasts / signalling

Subject area(s): Cell & Tissue Architecture | Membranes & Transport | Molecular Medicine | Signal Transduction