University of Oxford | United Kingdom
In my laboratory we investigate how bacteriocins use protein-protein interactions to translocate across the bacterial cell envelope. We also exploit bacteriocins as specific probes of cell envelope structure and organization in Gram-negative bacteria. We adopt a multidisciplinary approach in dissecting biological function that incorporates protein chemistry and engineering, molecular biophysics, structural biology and in-vivo imaging.
Keywords: Bacterial cell envelope / bacteriocin & immunity protein / outer membrane proteins / protein transport & translocation / protein-protein interactions