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EMBO Member

Colin Kleanthous

University of Oxford | United Kingdom

EMBO 2018

Bacterial protein-protein interactions

In my laboratory we investigate how bacteriocins use protein-protein interactions to translocate across the bacterial cell envelope. We also exploit bacteriocins as specific probes of cell envelope structure and organization in Gram-negative bacteria. We adopt a multidisciplinary approach in dissecting biological function that incorporates protein chemistry and engineering, molecular biophysics, structural biology and in-vivo imaging.

Keywords: Bacterial cell envelope / bacteriocin & immunity protein / outer membrane proteins / protein transport & translocation / protein-protein interactions

Subject area(s): Membranes & Transport | Microbiology, Virology & Pathogens | Proteins & Biochemistry | Structural Biology & Biophysics