Università, Siena | Italy
EMBO 2012 | GinC 19–22
My group studies the signaling pathways that orchestrate the assembly of the immunological synapse during T cell activation and their dysregulation in primary immunodeficiencies, autoimmunity and cancer. We are also interested in understanding how pathogens target these pathways to evade the immune defenses of the host.
Keywords: Signal transduction / antigen receptors / Shc adaptors / immunological synapse / host-pathogen interactions