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EMBO Young Investigator

Daniel Messerschmidt

Institute of Molecular and Cell Biology (IMCB), Singapore | Singapore

YIP 2018

Developmental epigenetics and disease

The research theme of my laboratory is developmental epigenetics. We study epigenetic dynamics in the mouse germline and preimplantation embryos. Our focus is on the mechanisms safeguarding the epigenome, the defects arising upon failure to do so, and the inheritance of the latter to the developing organism. Our ambition is to uncover targets and links causing complex epigenetic diseases and manipulate these in vivo.

Keywords: Epigenetics / transgenerational inheritance / epigenetic reprogramming / preimplantation development / embryogenesis / DNA methylation

Subject area(s): Chromatin & Transcription | Development | Genome Stability & Dynamics