Nuclear receptor signaling in the mouse
With the mouse as a mammalian model, and making an extensive use of site-directed cell-specific temporally-controlled somatic mutagenesis and transgenesis, our projects are aimed at characterizing the physiological role of nuclear receptors, the mechanism of their action at the molecular, cellular and organismal levels, and their implication in the pathogenesis of human diseases.
Keywords
Transcription / nuclear receptors / mouse genetics / muscle / cancer