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EMBO Member

Daniela Corda

CNR, Napoli | Italy

EMBO 2000 | WisC 08–12

ADP Ribosylation/lipid signalling/membrane fission

Our focus is on the role that mono-ADP-ribosylation plays in cell function, as demonstrated by us for the PARP12-control of intracellular membrane traffic. We are investigating the glycerophosphoinositols in the immuno-inflammatory responses. In parallel, we are defining at the molecular level the minimal components of the BARS-dependent fission machinery involved in several membrane traffic steps, by reconstitution and morphological approaches.

Keywords: Cell regulation / mono-ADP-ribosylation / lipid-derived second messengers / membrane fission / molecular medicine

Subject area(s): Membranes & Transport | Molecular Medicine | Proteins & Biochemistry | Signal Transduction