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EMBO Young Investigator

David Bikard

Institut Pasteur, Paris | France

YIP 2019–2023

Studying and fighting bacteria with CRISPR

My lab studies the prokaryotic immune system known as CRISPR-Cas. This system is able to capture pieces of DNA from invading genetic elements, and use this information to destroy cognate sequences through the action of RNA-guided nucleases. CRISPR-Cas systems have found a diversity of biotechnological applications. We are in particular interested in repurposing them to study and fight pathogenic bacteria.

Keywords: CRISPR-Cas / bacteriophage / synthetic biology / high-throughput screens / DNA repair

Subject area(s): Microbiology, Virology & Pathogens | Systems Biology