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EMBO Member

David C. Rubinsztein

Cambridge Institute for Medical Research (CIMR), Cambridge | United Kingdom

EMBO 2011

Huntington's disease, neurodegeneration and autophagy

My research aims to understand the pathogenesis of Huntington's disease and related conditions caused by aggregate-prone proteins, and towards developing rational therapeutic strategies. We have a major focus on understanding the relevance of autophagy defects as a disease mechanism and autophagy upregulation as a possible therapeutic approach, and study the basic cell biology of this important catabolic process.

Keywords: Huntington's disease / autophagy / polyglutamine disease / neurodegeneration / cell biology

Subject area(s): Membranes & Transport | Molecular Medicine | Neuroscience