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EMBO Member

David J. Owen

Institute for Medical Research (CIMR), Cambridge | United Kingdom

EMBO 2011

Transport vesicle and organelle biogenesis

Transmembrane proteins are moved between organelles in transport vesicles. The protein coats that surround transport vesicle possess both a self-assembly function, and cargo selection. In collaboration with other groups we take an integrated structural (X-ray crystallography)/functional approach to studying protein:protein and protein lipid interactions from a number of transport vesicle and organelle biogenesis events with an emphasis on cargo and SNARE selection and on the temporal and spatial regulation of the overall processes.

Keywords: Transport vesicle genesis / endocytosis / cargo selection / membrane fusion / organelle biology

Subject area(s): Membranes & Transport | Structural Biology & Biophysics