EMBO Member
David J. Owen
EMBO 2011
Former EMBO Young Investigator (2004)
Institute for Medical Research (CIMR), Cambridge, United Kingdom
Transport vesicle and organelle biogenesis
Transmembrane proteins are moved between organelles in transport vesicles. The protein coats that surround transport vesicle possess both a self-assembly function, and cargo selection. In collaboration with other groups we take an integrated structural (X-ray crystallography)/functional approach to studying protein:protein and protein lipid interactions from a number of transport vesicle and organelle biogenesis events with an emphasis on cargo and SNARE selection and on the temporal and spatial regulation of the overall processes.
Keywords
Transport vesicle genesis / endocytosis / cargo selection / membrane fusion / organelle biology