EMBO Member
David Komander
EMBO 2014
Former EMBO Young Investigator (2011)
Walter and Eliza Hall Institute, Parkville, Australia
Specificity in the ubiquitin system
We are interested in protein ubiquitination, and want to understand how proteins can distinguish between the different forms of ubiquitin chains in the cell, with the final goal to reveal cellular functions for unstudied atypical ubiquitin signals. We use a combination of biochemistry, biophysics, and structural biology, as well as cell biology and genetics to gain new insights into the ubiquitin system.
Keywords
Atypical ubiquitination / structural biology / enzyme mechanism / cell signalling / protein phosphorylation / non-proteinaceous ubiquitination