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EMBO Member

David Komander

Walter and Eliza Hall Institute, Parkville | Australia

EMBO 2014

Specificity in the ubiquitin system

We are interested in protein ubiquitination, and want to understand how proteins can distinguish between the different forms of ubiquitin chains in the cell, with the final goal to reveal cellular functions for unstudied atypical ubiquitin signals. We use a combination of biochemistry, biophysics, and structural biology, as well as cell biology and genetics to gain new insights into the ubiquitin system.

Keywords: Atypical ubiquitin chains / structural biology / deubiquitinase mechanism / cell signalling / protein phosphorylation

Subject area(s): Proteins & Biochemistry | Signal Transduction | Structural Biology & Biophysics