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EMBO Associate Member

David L. Vaux

Walter and Eliza Hall Institute, Parkville | Australia

EMBO 2012

Molecular mechanisms of cell death

My lab studies cell death. We found that bcl2 promotes cancer by inhibiting apoptosis, opening the molecular era of cell death research. By expressing bcl2 in C. elegans, we showed that apoptosis and programmed cell death are the same process. We identified several IAPs, and proteins that bind to them such as Diablo/Smac. While some IAPs are needed for cell division, we are studying how others (e.g. cIAP1) regulate signalling by TNF receptors.

Keywords: IAP / Bcl-2 / apoptosis / programmed cell death

Subject area(s): Differentiation & Death | Signal Transduction