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EMBO Member

David P. Lane

ST. ANDREWS | United Kingdom

EMBO 1988

Target validation in the p53 pathway

My group studies the p53 pathway from a whole animal to structural perspective with a special focus on the development of therapeutic approaches to cancer. Most recently we have worked intensely on the p53 Mdm2 protein-protein interaction developing stapled peptides that can activate the p53 response by blocking this interaction. We also have a strong interest in small molecule drug discovery using phenotypic screens and proteomics

Keywords: p53 / tumour suppressor genes / peptides / antibodies

Subject area(s): Differentiation & Death | Genome Stability & Dynamics | Molecular Medicine

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