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EMBO Member

David Wilkinson

Francis Crick Institute, London | United Kingdom

EMBO 2000 | FelC 08–12

Roles and regulation of boundary formation

We study mechanisms that underlie the formation and functions of boundary formation in the nervous system. We use gene manipulation and in vivo imaging in zebrafish, cell culture assays, and computer simulations to analyse how Eph receptor and ephrin signaling segregates cells and establishes sharp boundaries. In related work, we study how boundary cells form and pattern neurogenesis in the hindbrain.

Keywords: Vertebrate development / nervous system development / boundary formation / neurogenesis / cell signalling

Subject area(s): Development | Neuroscience | Signal Transduction