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EMBO Member

Deborah Fass

Weizmann Institute of Science, Rehovot | Israel

EMBO 2013

Catalysts of disulfide formation in proteins

My research group studies the catalysis of disulfide bond formation between cysteine amino acids in proteins. Enzymes that generate disulfide cross-links are key control points in assembling functional protein architectures. For example, we are investigating how a disulfide catalyst secreted from cells is involved in the assembly of the extracellular matrix, with potential applications in controlling cancer cell metastasis.

Keywords: Protein structure / flavoenzymes / disulfide bonds / extracellular matrix / enzyme inhibitors

Subject area(s): Proteins & Biochemistry | Structural Biology & Biophysics