University, Geneva | Switzerland
We study the in vivo functions of the Hsp90 molecular chaperone complex biochemically, pharmacologically, genetically (mouse, yeast, cell lines) and in silico. We also investigate the mitochondrial isoform Trap1, a master regulator of metabolism. A second major topic are the molecular mechanisms of signal transduction and integration by estrogen receptor alpha at the cellular level and its implications for breast cancer.
Keywords: Steroid receptors / signalling crosstalk / breast cancer / molecular chaperones / Hsp90