Molecular chaperone Hsp90 and steroid receptors
We study the in vivo functions of the Hsp90 molecular chaperone complex biochemically, pharmacologically, genetically (mouse, yeast, cell lines) and in silico. We also investigate the mitochondrial isoform Trap1, a master regulator of metabolism. A second major topic are the molecular mechanisms of signal transduction and integration by estrogen receptor alpha at the cellular level and its implications for breast cancer.
Keywords
Steroid receptors / signalling crosstalk / breast cancer / molecular chaperones / Hsp90