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EMBO Global Investigator

Dimple Notani

National Centre for Biological Sciences, Bangalore | India

GIN 2020–2024

Distal-regulatory elements and gene regulation

My group uses multidisciplinary approaches from single molecule tracking to genomics to understand the link among three-dimensional chromatin architecture, distal regulatory elements and associated eRNA in signalling driven gene regulation events. Recently, my group connected transcription-factor condensates on enhancers with ligand dependent gene regulation. These findings reveal how response to cyclic signalling events is robust.

Keywords: eRNA / enhancer RNA / three-dimensional chromatin architecture / genome organisation / loop extrusion / distal-regulatory elements / nuclear receptors

Subject area(s): Chromatin & Transcription | Genomic & Computational Biology | RNA | Signal Transduction