EMBO Global Investigator
National Centre for Biological Sciences, Bangalore | India
My group uses multidisciplinary approaches from single molecule tracking to genomics to understand the link among three-dimensional chromatin architecture, distal regulatory elements and associated eRNA in signalling driven gene regulation events. Recently, my group connected transcription-factor condensates on enhancers with ligand dependent gene regulation. These findings reveal how response to cyclic signalling events is robust.
Keywords: eRNA / enhancer RNA / three-dimensional chromatin architecture / genome organisation / loop extrusion / distal-regulatory elements / nuclear receptors
Subject area(s): Signal Transduction | RNA | Genomic & Computational Biology | Chromatin & Transcription