EMBO Member
Dirk Schübeler
EMBO 2009
Former EMBO Young Investigator (2007)
Friedrich Miesher Institute for Biomedical Research (FMI), Basel, Switzerland
Gene regulation in chromatin
Our group aims to understand the function of chromatin in genome regulation in higher eukaryotes. Chromatin itself is defined by a variety of measurable characteristics of a gene locus such as DNA methylation, histone modifications and DNA replication. In particular, we combine molecular biology and genomic approaches to generate comprehensive datasets which allow us to gain insights into sequence and structure determinants and to derive predictive models of regulation.
Keywords
Chromatin / DNA methylation / DNA replication / transcription / epigenetics